Leon said he is defending at UFC 300, so strong possibility...but Leon-Belal is not exactly a milestone-worthy headliner in the eyes of most fans.
They should move O'Malley-Chito to 300 as co-main in that case...if they are not going to have a 'blockbuster' main event, then at least having a series of great fights on the main card would be fine (IMHO - many may disagree and feel it needs to be more special).
Nate-Poirier could be another option.
There is a big chance of either a WSW, or WFLW title fight being on this card. Possibly both. An outside chance of a MW title fight. Islam is pushing for 299. They may hold off on O’Malley/Chito at 299, and move it to 300.
That’s at least 3 title fights, and actually 4 that could be available for 300. But Edwards vs Belal really would be anticlimactic as a ME.
But only 3 title fights take precedence over a WW title fight. That’s obviously MW, LHW, and HW title fights. And at least right now. It doesn’t look like there will be any of those on 300. That’s a pretty quick turnaround for Strickland/Dricus (but possible). Alex seems to be sitting out until Hill is ready. And both HW champs are probably sitting out, too.
(125) Pantoja should be available. (145) Alex V. is defending at 298. (135) O’Malley/Chito scheduled for 299. (155) Makhachev pushing for 299. (WW) Edwards vs Belal at 300. (MW) A quick but not impossible turnaround from 297 for Strickland/Dricus. (LHW) Alex apparently waiting for Hill (Hill might be healed enough.. but I’m not holding my breath). (HW) A fucking shitshow with neither champ fighting at 300.
(WBW) Vacant title fight at 297. I’d be very surprised if the winner turns around for 300. (WFLW) A possible trilogy fight with Shevchenko at 300. And outside chance of a superfight vs Weili. Erin/Manon are available to fight Alexa/Shevchenko at 300. Which is exponentially better than an instant trilogy. (WSW) I’ve been pretty sure for months Weili fights at 300. Yan, or Tatiana are the most likely opponents. Yan should be next. And there’s the superfight possibility with Alexa.
Those are the most likely title fights for UFC 300.