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It was never definite in the movie or the script, but Forest Gump was based off a novel by the same name. The novel has a sequel, "Gump and Co." , and in the novel it states that Jenny died from Hep C. This makes more sense to me...AIDS was pretty well identified by 1982 (when Jenny died), and the virus causing Hep C wasn't isolated until the late 1980's...seems like Hep C is the winner.
"Although many people assumed it was AIDs, the actual disease was not mentioned in the movie. She certainly doesn’t look like an AIDs sufferer as she is dying, however—no wasting, lesions, etc. In the book that’s the sequel to Forrest Gump, Gump and Co., author Winston Groom reveals that Jenny died of hepatitis C, a bloodborne illness which would probably have been the result of her intravenous drug use during her hippie years. There’s a very low rate of transmission through intercourse or from mother-to-child, which is why neither Forrest nor their son was infected."
http://newravel.com/pop-culture/film/forrest-gump-facts/9/
1) AIDS was not "pretty well identified" in '82; it only got named AIDS in '82.
2) He wrote Gump & Co in '94/'95, when Forrest Gump was in production. It was GRIDS/AIDS, and he changed it in the sequel to pander to the politics of the time.
3) Forrest Gump was released in '86; no one outside of medical labs and Michael Chrichton were thinking about hep C at the time.
4) Jenny got the bug during the height of GRIDS/AIDS days, not the height of Hep C.
5) Jenny not having the skin shit was politically cosmetic for the movie; can't offend specific folks by stating that debauch and deviancy cause disease, especially not after he just did Philadelphia. 90% of the studio's costume department would revolt.
GRIDS/AIDS is the the easy winner if you don't live in retcon universe.