Some additional tips in case you haven’t figured it out:
1. Save the small silphium vials for boss battles. I never buy the large silphium vials cause they’re too expensive. On a solid run you should be able to save up 5+ small vials. Pair that with repair enhancer and upgrade your repair efficiency every chance you get. You’ll eventually if not already be able to carry up to 3 items so going from biome to biome I take small silphiums, repair enhancers, and nullification spheres (optimally). If need be drop your small silphium somewhere next to a teleporter and then continue through biome to carry other things then once you’ve almost cleared the biome go back and pick it up. I sometimes do that in biome 2.
2. Once you reach biome 6 you’ll be able to skip all bosses on your way to biome 3 or 6. Right before fighting the boss you can cash in you leftover obolites in the obolites repository. I always exchange 300 obolites since you can’t take it with you regardless of whether you beat the boss or not. On your next run you’ll get a free item on your visit to the shop. A minor boost for your next run. Make sure the bar is not close to finishing cause if your deposit will complete it and the item drops immediately.
3. You can farm obolites in biome 4. The vines on the ground regenerate and there are a few areas that are rich in vines and always with or next to a teleporter. One of the reward rooms after one of the midbosses, the circular area leading up to biome 4 boss (the first floor), and an area that has two levels (teleporter on the lower level). The last one isn’t guaranteed to spawn but the first two will always be in your run. Vines respawn after you visit 2 different rooms so I basically teleport and rotate from these rooms and farm obolites. Spend 30-40 mins rotating from room to room and you’ll amass 1000+ obolites. dreadbound is the best weapon, point on the ground in front of you and continually run and dash.