Well, crime isn't exactly a small issue, so yeah, there's that(that "defund the Police" garbage is coming back to haunt the dems). There's also the immigration debacle, energy, and a sleeper issue with education. Now, I'm not going to get into the minutia of all the candidates' platforms and give you 900 links, but ultimately, like most elections, most are looking for an alternative if things are bad. Things are bad, and the Dems have total control. Hence, people are gonna look for a correction of sorts. The Republicans represent that, which is why they are poised to walk away with it.
In terms of inflation, you have an administration that denied it was happening for a good year. Will the Reps fix it? Probably not to any significant degree, but when the people in charge denied it was happening while spending TRILLIONS of dollars, in the face of average people seeing it coming a mile away, it speaks to their competence(or lack thereof). The Treasury Secretary literally admitted to not understanding certain elements of inflation. Not a good look, especially when the other side was raising the alarm the whole time.
To put it simply, this administration is failing on all sides. Why would people vote for more of it?