Supplements BPC 157 and TB 500

[period]

Should be interesting.

I am almost wondering if using them as suppositories would work better to bypass the first pass effect.

I look forward to read your results.

I should get the BCP 157 tomorrow or the day after, they wouldn't ship me the TB 500 here directly, so I'll have to go pick it up back home in Italy when visiting my parents in a week or two. I think I'll do the first month of each conventionally, and if I am satisfied with the effects, I'll continue that way. If not, I might consider your suggestion and see if that changes anything.
I'm using a number of other supplements as well (Rhodiola, Fenugreek, Tribulus and Tongkat, occasionally a cycle of Mumijo), but have been using them all for at least a year, so I should be able to spot any changes. I do plan on drastically reducing nicotine intake in the same time frame - I picked up the habit of using Snus from my teammates, and with my current monster deadlines, that has gotten out of hand - which will likely put a damper on my mood, but if anything should increase my body's healing capabilities.

 

[1rawdog]

@period

Should be interesting.

I am almost wondering if using them as suppositories would work better to bypass the first pass effect.

I look forward to read your results.

Good thinking but unless rectal is really a personal preference or the drug taste unbearably horrible I'd usually be thinking of sublingual before rectal, it's more reliable/consistent due to limiting factors of substances that may be in the way rectally.
Afaik everything taken SL bypasses the First Pass fully and faster than rectally which may only bypass at around 2/3 of the dose.

Edit - I can't remember what the supposed efficiency of these are via any other method than IM injection but it seems like from what I remember the preferred way is always injection and there is some debate, at least anecdotally, about proximity to an injury vs systemic effect. IDK anyone who has used them any other way than injection. Given all that and period only having the oral form available (right?) if I was him I'd be looking at one of these bypassing methods for sure,

 

[period]

@period

Good thinking but unless rectal is really a personal preference or the drug taste unbearably horrible I'd usually be thinking of sublingual before rectal, it's more reliable/consistent due to limiting factors of substances that may be in the way rectally.
Afaik everything taken SL bypasses the First Pass fully and faster than rectally which may only bypass at around 2/3 of the dose.

Edit - I can't remember what the supposed efficiency of these are via any other method than IM injection but it seems like from what I remember the preferred way is always injection and there is some debate, at least anecdotally, about proximity to an injury vs systemic effect. IDK anyone who has used them any other way than injection. Given all that and period only having the oral form available (right?) if I was him I'd be looking at one of these bypassing methods for sure,

Also a good idea. Yes, I could only get capsules, they supposedly have 500 mcg each of both compounds, so a rather high dose from what I gather. If I understand correctly, taking it sublingual would effectively increase the effective dose by bypassing the first pass. Again, something to consider if it doesn't have the desired effects in the first month.

 

[DEVILsSON]

@period

Good thinking but unless rectal is really a personal preference or the drug taste unbearably horrible I'd usually be thinking of sublingual before rectal, it's more reliable/consistent due to limiting factors of substances that may be in the way rectally.
Afaik everything taken SL bypasses the First Pass fully and faster than rectally which may only bypass at around 2/3 of the dose.

Edit - I can't remember what the supposed efficiency of these are via any other method than IM injection but it seems like from what I remember the preferred way is always injection and there is some debate, at least anecdotally, about proximity to an injury vs systemic effect. IDK anyone who has used them any other way than injection. Given all that and period only having the oral form available (right?) if I was him I'd be looking at one of these bypassing methods for sure,

Good points.

It ultimately comes down to the substance and amount. Some substances have incredibly high rectal/vaginal absorption. However my feeling is that because TB500 has such high molecular weight it will not be absorbed by anything other than SQ or IM injection.

TB500 is essentially useless unless injected from what I've seen. It's also important to make sure you get TB500 and not TB4 which is often used interchangeably however they are somewhat different and have different half lifes. TB4 has a half life of only 2 hours which is half of BPC. TB500 on the other hand has a very long half life of up to 10 days.

There's some conflicting information on BPC being absorbed orally. Acetate did zero for me but maybe newer arginate formulation can do something. People also tend to get more benefits for GI issues from the oral formulations than for musculoskeletal.

In my experience local injections tend to work better but that's anecdotal. I also prefer to use GHK-cu along with the other two as it serves as an injury marker along its other properties.

 

[period]

Good points.

It ultimately comes down to the substance and amount. Some substances have incredibly high rectal/vaginal absorption. However my feeling is that because TB500 has such high molecular weight it will not be absorbed by anything other than SQ or IM injection.

TB500 is essentially useless unless injected from what I've seen. It's also important to make sure you get TB500 and not TB4 which is often used interchangeably however they are somewhat different and have different half lifes. TB4 has a half life of only 2 hours which is half of BPC. TB500 on the other hand has a very long half life of up to 10 days.

There's some conflicting information on BPC being absorbed orally. Acetate did zero for me but maybe newer arginate formulation can do something. People also tend to get more benefits for GI issues from the oral formulations than for musculoskeletal.

In my experience local injections tend to work better but that's anecdotal. I also prefer to use GHK-cu along with the other two as it serves as an injury marker along its other properties.

We'll see. I am mostly curious and don't expect much, so while we can never rule out placebo effect completely, it shouldn't be too pronounced. If the stack doesn't work as intended, I'll also throw in some ostarine and some cissus - I had good experiences with that in the past. Shotgun approach...

 

[minowasmullet]

Where is reputable to buy. I have a dislocated thumb that never really healed properly coupled with achilles tendonitis and a dicky hip flexor/groin. None seem to go away with rest and flare up again (often worse) when I start training/sport again so just play through it now.

I've watched to give BPC157 and TB500 a go but injecting something bought off the unregulated internet is pretty hardcore. I don't know anyone personally who's used it to get good references/stories...

If Australia if that matters

I keep forgetting to reply to this im in Aus and was getting it from Alkaline Superfoods but TGA just closed them down recently. Im a pretty big believer in the tablet form (im just taking one every morning) you drop good boxing betting stuff so if you want you can message me for more info happy to send you some to try if youre unsure too no drama

 

[1rawdog]

We'll see. I am mostly curious and don't expect much, so while we can never rule out placebo effect completely, it shouldn't be too pronounced. If the stack doesn't work as intended, I'll also throw in some ostarine and some cissus - I had good experiences with that in the past. Shotgun approach...

I'll take all the placebo i can afford as long as it works !

 

[period]

I'll take all the placebo i can afford as long as it works !

Quote of the day Ain't that true...

 

[period]

Short report on my supplement approach: so I was in quite a bit of pain mid-week (things that had been dragging on got worse - irritated tendons and old muscle tears... it got to the point where I got pain spikes when not moving carefully or flexing the concerned areas), despite the BCP 157 and TB 500. So I spontaneously decided to go over to the dark side and additionally pop some Ostarine capsules (Swiss Pharmaceuticals, 10 mg).
Well, believe it or not (I sure don't, really - I can't explain it, but it is what it is): a mere three days in and all the pain is GONE. It actually got noticeably better already on day 1, and was greatly reduced on day 2.

 

[1rawdog]

Short report on my supplement approach: so I was in quite a bit of pain mid-week (things that had been dragging on got worse - irritated tendons and old muscle tears... it got to the point where I got pain spikes when not moving carefully or flexing the concerned areas), despite the BCP 157 and TB 500. So I spontaneously decided to go over to the dark side and additionally pop some Ostarine capsules (Swiss Pharmaceuticals, 10 mg).
Well, believe it or not (I sure don't, really - I can't explain it, but it is what it is): a mere three days in and all the pain is GONE. It actually got noticeably better already on day 1, and was greatly reduced on day 2.

I believe you. Could be explained by a number of mechanism or factors, I'm all for staying the course when shit is working, I wish you well, keep your eyes open for both the good and bad.

 

[period]

I believe you. Could be explained by a number of mechanism or factors, I'm all for staying the course when shit is working, I wish you well, keep your eyes open for both the good and bad.

It's as close to magic as I anything have witnessed so far. I had pondered on the decision to take Ostarine for a while, since apparently, there have been some weird side effects (liver damage and whatnot). Also, this is the first time ever I that I have taken something that is technically speaking a banned substance on most PED lists as far as I can see (found that out a few days after ordering it). But so far, I can't complain; also, I am not competing currently, nor will I be in the foreseeable future (maybe next year, if I stay relatively injury-free and my old ones don't act up too much).

 

[Deaths Head]

I'm interested in this stuff, just got some and gonna give it a go to try and treat patella tendonitis. I'm going to post all relevant info here.

If you've had any experience please contribute!

Examine.com:

"BPC-157 is a peptide chain consisting of 15 amino acids. It is considered synthetic because this particular sequence does not exist in nature. It is derived from a protective protein found in the stomach.

Researchers have conducted numerous rodent studies on BPC-157 that show it has protective effects extending beyond the stomach and intestinal tract. BPC-157 has been shown to benefit ulcers in the stomach, intestinal damage such as fistulas and inflammatory disorders, bone and joint healing and growth rates, and organ damage. It also has some influences on the brain. Researchers have observed marked protective effects when BPC-157 is administired to rats alongside a research toxin or damaging surgical procedure.

More research is needed to clarify whether BPC-157 has multiple mechanisms of action, but current research suggests BPC-157 influences several growth factors usually involved in angiogenesis (the production of blood vessels) and other factors involved in regeneration following damage.

BPC-157 shows promise, but human studies are needed to demonstrate that these benefits extend beyond research animals.

The majority of studies on BPC-157 are done on rats given injections of the supplement. While BPC-157 is a stable peptide, peptides are a group of compounds that are normally poorly absorbed after oral supplementation, so researchers use injections in rodent studies instead. Furthermore, there is no human evidence for BPC-157 and the majority of the research has been conducted by a single research group. Due to its synthetic nature, there may be legal issues associated with the sale of this supplement in certain regions and it may be banned by some sport organizations."

My cousin has severe diabetes and started taking the BPC it’s helping his foot ulcer sores , I also have a friend who has Chromes disease it helps his stomach, my older brother is also on it now I don’t know why ? I didn’t ask him anyway it seems to work they do the injections not the pills .

The U.S FDA bans this so that tells me it works and they don’t want anyone skipping medication day by prescription through big pharma .

 

[Krixes]

My cousin has severe diabetes and started taking the BPC it’s helping his foot ulcer sores , I also have a friend who has Chromes disease it helps his stomach, my older brother is also on it now I don’t know why ? I didn’t ask him anyway it seems to work they do the injections not the pills .

The U.S FDA bans this so that tells me it works and they don’t want anyone skipping medication day by prescription through big pharma .

My Dad started injecting BPC 157 after his knee replacement surgery, and shoulder surgeries. He swears by the stuff, said he was feeling a lot better 3 weeks later. He's in in his 70's, golfs 4 days a week, lifts 3-4 days a week, swims almost everyday. He puts me to shame, I'm the runt of the litter though...

He gets from a real good place in Tucson, AZ. I forgot the name of it but I'm sure a quick search would show the name.

 

[Deaths Head]

My Dad started injecting BPC 157 after his knee replacement surgery, and shoulder surgeries. He swears by the stuff, said he was feeling a lot better 3 weeks later. He's in in his 70's, golfs 4 days a week, lifts 3-4 days a week, swims almost everyday. He puts me to shame, I'm the runt of the litter though...

He gets from a real good place in Tucson, AZ. I forgot the name of it but I'm sure a quick search would show the name.

I’m 51 and didn’t have a great relationship with my father I actually had to beat him in arm wrestling when I was 13 and he was pretty strong guy that’s whEn the bullying stopped ,

I was the smallest person in my family with everyone included but I had freak strength I even threw a 10 pound shovel when I was 8 about 30 feet according and it crashed three this poor old guys window and me and my friend ran up in his addick playinligjt bright but we were caught ( lol ) anyway my father is 85 and still competes in dancing competition he’s a former champion ( that’s why o got great footwork for fighting …lol .

At the end of the day a.ways encourage your fans to take anything if it’s a benefit,unfair no one listens to me in my family but ..it is what it is I could have expand their life at least 7 years . I myself a.ways look to reverse the age proof as you know …

51 and I’m looking to break things .and in some cases real ppl you might actually see that soon there always that guy and ….? Lol

 

[maximus__]

I’m 51 and didn’t have a great relationship with my father I actually had to beat him in arm wrestling when I was 13 and he was pretty strong guy that’s whEn the bullying stopped ,

I was the smallest person in my family with everyone included but I had freak strength I even threw a 10 pound shovel when I was 8 about 30 feet according and it crashed three this poor old guys window and me and my friend ran up in his addick playinligjt bright but we were caught ( lol ) anyway my father is 85 and still competes in dancing competition he’s a former champion ( that’s why o got great footwork for fighting …lol .

At the end of the day a.ways encourage your fans to take anything if it’s a benefit,unfair no one listens to me in my family but ..it is what it is I could have expand their life at least 7 years . I myself a.ways look to reverse the age proof as you know …

51 and I’m looking to break things .and in some cases real ppl you might actually see that soon there always that guy and ….? Lol

@1rawdog Did we ever get that curl video?

 

[1rawdog]

@1rawdog Did we ever get that curl video?

Obviously that's not a serious question! I don't have time for aussie jokes my friend, I'm very busy with my new training program, these rocks are not going to push-punch themselves bro

 

[BroScienceTalkatWork]

Always valuable to gather non Reddit anecdotes. Those fucking hypochondriac dweebs

“Don’t take TB 500! Got a case of gout that’s been sticking around for 2 years “

As a adderall guy.. I hesitated on bpc for a while cause it supposedly blunts the dopamine response. But I’m picking some up. Tendonitis during a cut is a motherfucker

 

[DEVILsSON]

Always valuable to gather non Reddit anecdotes. Those fucking hypochondriac dweebs

“Don’t take TB 500! Got a case of gout that’s been sticking around for 2 years “

As a adderall guy.. I hesitated on bpc for a while cause it supposedly blunts the dopamine response. But I’m picking some up. Tendonitis during a cut is a motherfucker

They are both great but there are some risks.

BPC can cause anhedonia in something like 1-2%(I am pulling these numbers out of my ass) of people.

It is my conjecture TB500 can help spread existing cancer and or make it more aggressive. I found out the hard way. It is a trip. I had a tiny pin sized ulcer that wouldn't heal for over six months with TB500 it healed so well that by the time I went to see a dermatologist he couldn't tell anything was wrong even under 100x magnification. Only a biopsy raised the alarm. The cancer was extremely aggressive and atypical. It was so aggressive they couldn't initially pin down which specific cancer it was.

I still use both but you need to go into it with eyes wide open.

I may be wrong but I get the sense you approach AAS and these other research chemicals in a fairly non chalant manner. I'd be a bit more cautious. Don't get caught slipping like me.

I now take massive amounts of melatonin in part to prevent cancer. Methylene Blue is likewise purported to help prevent or slow down cancer.

 

[BroScienceTalkatWork]

They are both great but there are some risks.

BPC can cause anhedonia in something like 1-2%(I am pulling these numbers out of my ass) of people.

It is my conjecture TB500 can help spread existing cancer and or make it more aggressive. I found out the hard way. It is a trip. I had a tiny pin sized ulcer that wouldn't heal for over six months with TB500 it healed so well that by the time I went to see a dermatologist he couldn't tell anything was wrong even under 100x magnification. Only a biopsy raised the alarm. The cancer was extremely aggressive and atypical. It was so aggressive they couldn't initially pin down which specific cancer it was.

I still use both but you need to go into it with eyes wide open.

I may be wrong but I get the sense you approach AAS and these other research chemicals in a fairly non chalant manner. I'd be a bit more cautious. Don't get caught slipping like me.

I now take massive amounts of melatonin in part to prevent cancer. Methylene Blue is likewise purported to help prevent or slow down cancer.

I do approach some of this shit recklessly:: I’m not planning on living this lifestyle forever.

hit my physique goals in 8 months to a year. Until then I’m going all out

As far as BPC goes —- addnhonia scares me but I also heard so much hysteria with Finasteride that I take everything with a grain of salt

 

[DEVILsSON]

I do approach some of this shit recklessly:: I’m not planning on living this lifestyle forever.

hit my physique goals in 8 months to a year. Until then I’m going all out

As far as BPC goes —- addnhonia scares me but I also heard so much hysteria with Finasteride that I take everything with a grain of salt

I approach research chemicals with a Biohackers mindset.

Firstly make sure the LD50 is reasonably high compared to what you plan to use. 100x is usually a good idea.

Secondly start low and slowly increase the amount over time. If you notice side effects then stop or drop down.

You can do a lot of damage in eight months so don't play around. Use your head.