BPC 157 and TB 500

Smato_rules said:
Is anyone concerned about the negative side effects? All I’ve read is it could potentially cause cancer to grow if you already have it, but I haven’t heard anyone complain about it anywhere
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People say that because of vegf and the fact it accelerates growth but there is some research now saying it may have a powerful anti cancer effect.
 
RabbitPunch36 said:
I can't believe sherdog already about peptides back in 2017. Where or who did the og's first hear about bpc and tb500 from?
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Bodybuilders I think. Ben Greenfield wrote something on it pretty early, 2016 I think. That's where I first got reasonable information from.
 
RabbitPunch36 said:
Has your wife tried pemf?
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No, but we go barefoot a bunch. Her issue is related to a genetic condition leading to more flexible collagen rather than inflammation but that's not to say it wouldn't help. I should probably wire the bed to the ground outside.
 
Phlog said:
No, but we go barefoot a bunch. Her issue is related to a genetic condition leading to more flexible collagen rather than inflammation but that's not to say it wouldn't help. I should probably wire the bed to the ground outside.
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Eller danlos? I don't know if you have heard of or tried cartalax and ghk cu but I have heard good things about them for people with connective tissue disorders.
 
I’m gonna be using both of these for my Achilles tendon rupture recovery. I sure hope they speed up the post surgery recovery because it sounds fucking terrible
 
Phlog said:
I thought I'd bump this a few years later.

I've used bpc157 3 times now, each time it's been a dramatic effect. Used it for knee pain and inflammation, a broken hand and just now for a tricep tear that might be a detachment, I'm waiting on a scan.

Interestingly this last time I've used it orally and straight after the injury, swelling and pain reduced markedly over the first 56hrs. I think it's worth having it on hand to administer immediately after injury.

I administered it on my wife who has a degenerative back condition and it was instrumental in turning her issues back a few years such that she can now do tai chi, dance and work out to a limited extent. She was getting to the point where nothing helped, she managed to come off all the pain killers as a result.

I believe it is one of the most powerful tools available to us in injury or damage repair. Fingers crossed it's not linked with cancer or something in the future.
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So you had success with the oral stuff? Everyone I know that uses it recommends injecting it.

It able to be used (under doc supervision) where I am now.
 
Smato_rules said:
I’m gonna be using both of these for my Achilles tendon rupture recovery. I sure hope they speed up the post surgery recovery because it sounds fucking terrible
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Not a full rupture, but I had a pull that then felt like a partial tear. It took me 6 months to come back from with hard rehab.
 
Smato_rules said:
Damn, yeah it sounds like a rough road ahead for me. This sucks
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Man just rehab it hard. I do isometrics near daily still.
I do them pre training, post training, in the shower and when I am just standing around.
 
Maybe more fighters should try this stuff.

<mma4>

BPC-157 (Body Protective Compound-157) is a synthetic peptide derived from a protective protein found in the stomach. It has gained attention in animal studies for its potential healing effects, including promoting tissue repair, reducing inflammation, and improving blood vessel formation.


Regarding Brain Injury:​


In animal studies, particularly in rodents, BPC-157 has shown neuroprotective effects. These include:


  • Reduced brain damage after traumatic brain injury (TBI).
  • Protection against stroke-related damage.
  • Improved healing of peripheral nerve injuries.
  • Reduced inflammation and oxidative stress in the brain.

Mechanisms proposed include:


  • Promoting angiogenesis (formation of new blood vessels).
  • Modulating neurotransmitter systems (dopamine, serotonin).
  • Reducing oxidative stress and inflammation.

However — Key Limitations:​


  • No high-quality human trials have been published demonstrating that BPC-157 can repair brain injury in people.
  • Most evidence is preclinical (animal-based) and not sufficient to confirm efficacy or safety in humans.
  • BPC-157 is not approved by the FDA or EMA for medical use, and its legal status varies by country.

Conclusion:​


BPC-157 shows promising results in animal models for brain injury repair, but there is no solid evidence yet in humans. If you're considering BPC-157 or other experimental treatments for brain injury, it’s important to consult a knowledgeable physician or neurologist.


Would you like a summary of the key studies or potential risks?
 
maximus__ said:
So you had success with the oral stuff? Everyone I know that uses it recommends injecting it.

It able to be used (under doc supervision) where I am now.
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Yes the oral seemed to work but I know the injecting does for sure.
SSgt Dickweed said:
Maybe more fighters should try this stuff.

<mma4>

BPC-157 (Body Protective Compound-157) is a synthetic peptide derived from a protective protein found in the stomach. It has gained attention in animal studies for its potential healing effects, including promoting tissue repair, reducing inflammation, and improving blood vessel formation.


Regarding Brain Injury:​


In animal studies, particularly in rodents, BPC-157 has shown neuroprotective effects. These include:


  • Reduced brain damage after traumatic brain injury (TBI).
  • Protection against stroke-related damage.
  • Improved healing of peripheral nerve injuries.
  • Reduced inflammation and oxidative stress in the brain.

Mechanisms proposed include:


  • Promoting angiogenesis (formation of new blood vessels).
  • Modulating neurotransmitter systems (dopamine, serotonin).
  • Reducing oxidative stress and inflammation.

However — Key Limitations:​


  • No high-quality human trials have been published demonstrating that BPC-157 can repair brain injury in people.
  • Most evidence is preclinical (animal-based) and not sufficient to confirm efficacy or safety in humans.
  • BPC-157 is not approved by the FDA or EMA for medical use, and its legal status varies by country.

Conclusion:​


BPC-157 shows promising results in animal models for brain injury repair, but there is no solid evidence yet in humans. If you're considering BPC-157 or other experimental treatments for brain injury, it’s important to consult a knowledgeable physician or neurologist.


Would you like a summary of the key studies or potential risks?
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They absolutely do, I heard about it first from a fighter! It's great stuff. I hope no major downsides are found long-term.
 
Smato_rules said:
I’m gonna be using both of these for my Achilles tendon rupture recovery. I sure hope they speed up the post surgery recovery because it sounds fucking terrible
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Pin at the ankle/calf area. The consensus is mixed but in my experience it works better when pinned locally to where the injury is. BPC157 has a relatively short half life of around 4 hours iirc. It doesn't matter as much for TB500 since it's half life is quite long of 7-10 days....I have pinned into a finger after it would not heal with pinning into shoulder/etc. Your injection volume will need to be smaller the smaller the area. In the ankle or calf area you can do up to 1ml but in a finger 20 units is probably max.

You may also want to use GHK-cu with the other two peptides. It works as an injury marker.

A relative of mine cut her recovery in half after a fracture with mostly BPC157 for a couple weeks and then TB500 added on top towards the last few weeks. So this stuff is quite awesome.

Only significant caution is if you have active cancer. It may make it atypical and aggressive. I found out the hard way.

Obviously also follow common sense approach of starting low, testing for allergies/sensitivities, etc and then raising dose gradually. I needed 1mg of each per day to get tendinitis in check. BPC157 can cause anhedonia in a small number of people.
 
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DEVILsSON said:
Pin at the ankle/calf area. The consensus is mixed but in my experience it works better when pinned locally to where the injury is. BPC157 has a relatively short half life of around 4 hours iirc. It doesn't matter as much for TB500 since it's half life is quite long of 7-10 days....I have pinned into a finger after it would not heal with pinning into shoulder/etc. Your injection volume will need to be smaller the smaller the area. In the ankle or calf area you can do up to 1ml but in a finger 20 units is probably max.

You may also want to use GHK-cu with the other two peptides. It works as an injury marker.

A relative of mine cut her recovery in half after a fracture with mostly BPC157 for a couple weeks and then TB500 added on top towards the last few weeks. So this stuff is quite awesome.

Only significant caution is if you have active cancer. It may make it atypical and aggressive. I found out the hard way.

Obviously also follow common sense approach of starting low, testing for allergies/sensitivities, etc and then raising dose gradually. I needed 1mg of each per day to get tendinitis in check. BPC157 can cause anhedonia in a small number of people.
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Where is reputable to buy. I have a dislocated thumb that never really healed properly coupled with achilles tendonitis and a dicky hip flexor/groin. None seem to go away with rest and flare up again (often worse) when I start training/sport again so just play through it now.

I've watched to give BPC157 and TB500 a go but injecting something bought off the unregulated internet is pretty hardcore. I don't know anyone personally who's used it to get good references/stories...

If Australia if that matters
 
burge13 said:
Where is reputable to buy. I have a dislocated thumb that never really healed properly coupled with achilles tendonitis and a dicky hip flexor/groin. None seem to go away with rest and flare up again (often worse) when I start training/sport again so just play through it now.

I've watched to give BPC157 and TB500 a go but injecting something bought off the unregulated internet is pretty hardcore. I don't know anyone personally who's used it to get good references/stories...

If Australia if that matters
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For bpc I'd give 'pharmalabglobal' a try. They tend to have the best prices and the quality seems comparable to others. Make the most of your first order as you get 10% off. They also sometimes have big sales like during Christmas when they discount everything by 10-20%.

For tb500 'swisschems.is' is probably the best as far as price and quality.

You may also want to look into ghk-cu. There are a few sites that sell it. Just make sure it's blue. I got scammed once by a site that no longer exists. I just found 'solutionpeptides.net' but based off reddit it seems decent.

For BAC water for reconstitution I'd go with ebac-water.com. They have the best prices I've found.

For syringes you can try Amazon. I suggest 30 or 31 gauge. The higher the number the smaller the needle. You can use these syringes for reconstitution also or get slightly bigger ones like 25 gauge.
 
DEVILsSON said:
For bpc I'd give 'pharmalabglobal' a try. They tend to have the best prices and the quality seems comparable to others. Make the most of your first order as you get 10% off. They also sometimes have big sales like during Christmas when they discount everything by 10-20%.

For tb500 'swisschems.is' is probably the best as far as price and quality.

You may also want to look into ghk-cu. There are a few sites that sell it. Just make sure it's blue. I got scammed once by a site that no longer exists. I just found 'solutionpeptides.net' but based off reddit it seems decent.

For BAC water for reconstitution I'd go with ebac-water.com. They have the best prices I've found.

For syringes you can try Amazon. I suggest 30 or 31 gauge. The higher the number the smaller the needle. You can use these syringes for reconstitution also or get slightly bigger ones like 25 gauge.
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thanks, pharmalabglobal is one i have bookmarked so guess I was on the right track somewhat

Would the nasal sprays or capsules work as well as injections? I'd love to avoid injections wherever possible
 
burge13 said:
thanks, pharmalabglobal is one i have bookmarked so guess I was on the right track somewhat

Would the nasal sprays or capsules work as well as injections? I'd love to avoid injections wherever possible
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You can try BPC157 arginate pills. They will be inferior to injections but they may help. I tried the older acetate version and it was 150$ down the drain. The only way they slightly worked was when I did microneedling of the skin and then emptied out the contents of the capsule and applied it over the punctured skin with some DMSO gel.

TB500 has too high of molecular weight and cannot be taken in pill form AFAIK. Some places do sell the pill form but it's almost certainly a waste of money.

GHK-CU can be applied topically but may work in a different way than when injected.

It is best to inject. For BPC it's also best to inject it as close to injury source as practical so for you that may be the thumb. I have done it for ring finger and it's not too bad at all. TB500 it doesn't matter as much due to very long half life.
 
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