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It matters, but if you aim at the knee its gonna mess up the knee, wether there is weight on it or not, unless you are super delicate with it, and then it defeats the purpose of the kick.
Of course, every strike is gonna mess up the body part it is aimed at. The problem is how much it gonna mess up. If you have weight over it then you are gonna damage it really bad next time someone land such kicks. It is like a leg kick, if you have your lead leg light and ready then the leg kick isn't as hurtful as when you have your lead leg heavy.