Interesting thing happened over the weekend:
I was playing the Companions story line and got to the point where I turned into a werewolf. I woke up outside that base and had to finish clearing out a Silver Hand base to complete the quest line I was on. I finish the quest, do a couple of other things, then and go back to my homestead to pick up Lydia. A courier comes up to me with a notice about an inheritance. I read it and apparently Adrienne (the Whiterun black smith) died. I figure some vampires must have spawned when I turned into a werewolf or something. I thought about going back and trying to save her, but my last hard save before that would have set be back several hours. I said fuck it, she's gone now, so I've decided to do the Dawnguard quest to avenge her.
On a sad note, if you go to her husband and ask who makes the weapons or armor, he sounds pretty sad. He's trading with Kahjit for now. He tried smithing on his own, but could never get it right. It's a great little detail the developers put in there.