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That fight proved Reem has so so cardio. JDS was a little gased in the 3rd round vs Nelson but nowhere near as Reem. I doubt this will be a factor if they ever fight but crazier things have happened.
The interesting thing about Overeem's fights is that they all look very different, it's impossible to know what kind of finish we'll get from him, he's done it all.
Testosterone increases the number of red blood cells you have, thickening the blood, not to mention all of the muscles it adds that need to be fed oxygen. Cardio could be a factor for sure, that would certainly be taken into account if JDS preps for GMOvereem.