Are there market and political ideological forces tilting the narrative and potentially affecting the course of the research? There is, and there
always have been.
There are financial and political interests everywhere. That does not discredit the procedure of scientific practice in general, nor the work of the doctors and scientists doing the medical trial testing. Far less does it justify extrapolating its use before the completion of trials and research.
You are oversimplifying the safety profile of the drug. Invermectin has been used in controlled contexts for onchocerciasis and lymphatic filariasis, and Muñoz's (2021) study was over a sample of 54
healthy adults who showed no significant symptoms.
That is
not the same as proving that the drug is safe for patients who might not be healthy adults, or who have pre-existing conditions of some sort. Clinical trials have to be carried relative to the candidate patient pool, in consideration of collateral conditions. The obvious ones are pregnancy, or pre-existing medical risk factors like diabetes or obesity which make it extremely important to do test controls.
In the case of COVID and invermectin, there have been several studies that suggest safety factors are high but with mixed results in treatment: Krolewiecki (2021) shows a correlation between mean plasma levels and viral load concentrations;
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(21)00239-X/fulltext
Bounfate and Chesini (2021) show no significant risk for high-dosage but also no significant reduction in viral loads.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3918289
Vallejos (2021) indicates that results do not mitigate the risk of hospitalization:
https://pubmed.ncbi.nlm.nih.gov/34215210/
FDA studies and many independent organizations have shown serious medical complications with patients with pre.existing conditions with hospitalizations. There seems to be a correlation with the use of blood thinners and adverse effects, which would be critical to map since many older people take medicines for heart disease, etc.
https://www.nejm.org/doi/full/10.1056/NEJMc2114907
https://www.clinicaltrials.gov/ct2/...ectin&cntry=&state=&city=&dist=&Search=Search
Heidary (2020) already established the necessity for extensive clinical trials.
https://www.nature.com/articles/s41429-020-0336-z
The result of rigorous studies will be a much clearer sense of just when, how, and who the drug might help and be prescribed to safely.
I'm not saying there weren't and aren't political and market distortions. I'm saying Joe Rogan is an irresponsible sack of shit extrapolating from individual experience and partial information. You can't do that.