Social WR lounge 265: Rigging the game.

Rate bigwaverider as a mod

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@Unknown Pleasures



Montreal 'Marlboro Trunks' Dooran might just represent the ultimate peak in what was arguably the greatest single win in boxing history. The Palomino and DeJesus IiI performances were fucking sick too. And with that, I must update my current fave list.

01. Roberto Duran
02. Pernell Whitaker
03. Ray Robinson
04. Mike McCallum
05. Julio Cesar Chavez, Sr.
 
In commemoration of Hockey’s recent face off, I unofficially declare the WR area code to be 409, representing the 40.9% of the vote total he managed to pull in.
 
Lead said:
In commemoration of Hockey’s recent face off, I unofficially declare the WR area code to be 409, representing the 40.9% of the vote total he managed to pull in.
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Shut up, quitter. If you only had balls during my reign you'd wouldn't have bowed out on the POTWR business. Now you wanna "declare" some shit?


<{cruzshake}>
 
Cubo de Sangre said:
Two employers in the last 22 years and in the same "profession" for the last 17 (or so).



A good 25% of my contacts on the site are recruiters (aka headhunters). Due to factors they've nothing to offer me in terms of advancing my career. When I say I've no interest in driving further for less money they come up empty.

Two years ago I took an interview, right in the height of the NBA free agency recruiting season. Taking a page out of Kawai's book, I went in asking what they could do for me, and how bad do they want it. Unlike KL, things didn't really progress from there. But joke's on them, it would have been a sizable paycut and the atmosphere seemed shitty. The one allure was they have a shooting range and that would have save me a ton of driving and allowed for more frequent opportunity to hone the skills.

So yeah, Linkedin was never my friend.
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When my niece was born my brother's friend showed up. He is the manager for my locals health and welfare fund.
Him: heard about getting the boot from NIU and the wasted year in Fl
Me: yup
Him: how much did that cost you?
Me: I think I'm down in total 45k
Him: oof. Its ok cuz after Monday you'll be able to start recouping quickly
Me: Monday....wut?
Him: yeah, you're signing up for the apprenticeship
Me: nah I'm good
Him: this isn't me asking. It's your mom telling
Me......
Him: after you fill out the paperwork go here and they'll be waiting for you
 
Rebelfett said:
Umm....... no.
I really thought we were better friends. You don't even know where I'm from
<mma1>
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I-I don't even know what I said to offend you then! But even still, I'm sorry...
tenor.gif
 
essie said:
not at the moment i dont.
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:(

That's hard to believe.

You wanna borrow my twink for platonic purposes?

Rebelfett said:
@Deorum
What kind of injections are those? Is everything OK?
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Yeah, all good. They're just vanity injections and one of the things I've started utilizing to offset the damaging effects of my smoking habit.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining.

GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system.

Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK.

Up-to-date, it is established that GHK-Cu is able to:

-Tighten loose skin and reverse thinning of aged skin

-Repair protective skin barrier proteins

-Improve skin firmness, elasticity, and clarity

-Reduce fine lines, depth of wrinkles, and improve structure of aged skin

-Smooth rough skin

-Reduce photodamage, mottled hyperpigmentation, skin spots and lesions

-Improve overall skin appearance

-Stimulate wound healing

-Protect skin cells from UV radiation

-Reduce inflammation and free radical damage

-Increase hair growth and thickness, enlarge hair follicle size

Most authors would attribute effects of GHK to its ability to bind copper(II) ions. It was proposed that because of the GHK’s small size and its ability to bind copper, it can play a crucial part in copper metabolism [2]. However, since 2010, a new mechanism has started to emerge. The Broad Institute of MIT and Harvard has created the Connectivity Map—a publicly available library of transcriptional responses to known perturbagens, substances that modulate gene expression [3].

This tool allowed researchers to investigate genome-wide effects of GHK and establish that GHK-Cu is able to up- and down-regulate a significant number of human genes. Today, it has become possible to connect biological effects of GHK-Cu and its effects on gene expression, to develop a more comprehensive view on GHK’s mechanism of action [4].

The present paper reviews protective and regenerative actions of the GHK-Cu peptide in human skin, as well as new gene data, revealing possible mechanisms behind these actions.
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Deorum said:
:(

That's hard to believe.

You wanna borrow my twink for platonic purposes?



Yeah, all good. They're just vanity injections and one of the things I've started utilizing to offset the damaging effects of my smoking habit.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
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Oh. Or you know...... you could stop smoking.
:p
 
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