If you lived through the 90's, you already know the dangers of "weight loss" drugs. That said, if you're 400lbs you may as well pick your poison and go for it. The people looking to lose 10-20lbs with a quick fix are gonna be the ones regretting their choices.
But hey, if they find a weight loss drug that works for everyone, more power to them. I've been conditioned to believe that there is always a price to pay for this shit. Usually is, when your body is being transformed at a rapid pace by a drug, but you never know.