Zankou, I've led with the rear-hook a couple times, but it is specifically to isolate and strengthen the knockout punch. The power-hand hook. I don't believe in never training it up just because it's always going to be strong, timing, accuracy, and speed can always be improved upon.
I devote the 5th and 6th round in my routine to combinations, I just never do the same ones over and over. I like to adlib and totally switch-up my arsenal day-to-day for versatility. Like sometimes I start out with your traditional 1-2, and vary it by going body-head, then I might actualy reverse it and go 2-1 (I throw jabs last when someone is backing me up, jabbing while backpedaling is an awesome tool to have), and then from there I mentally go somehweres else if you know what I mean. I'm not thinking "what combo do I do next?"....I'm just belting away and circling, measuring, feinting, and with the bag swinging the whole time it gives me a good idea of counter-punching angles.