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Food & Drink The M. vaccae shot: Obesity vaccine could make us ‘immune’ to gaining weight from a high-fat, high-sugar diet

Even without weight gain such a diet will contribute to a higher risk of heart disease, chronic inflammation, fatty liver disease, diabetes, etc…
Yes but it can still help.

It gives people a chance. That's invaluable.
 
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Researchers at the University of Colorado Boulder may have found the mechanisms for a groundbreaking vaccine that could help people keep their weight in check by tapping into the power of healthy bacteria.

In a study published this week in the journal Brain, Behavior and Immunity, mice injected with a micro-organism found in cow’s milk and soil were essentially immune to the weight gain typically caused by a high-fat, high-sugar diet.


“What is so striking about this study is that we saw a complete prevention of diet-related weight gain in these animals,” said senior author Christopher Lowry, professor of integrative physiology.

“This suggests that exposure to beneficial bacteria can protect us against some of the negative health outcomes of the typical Western diet.”

If proven effective, the M. vaccae shot could offer a new weight-loss solution for those battling America’s obesity crisis, which affects an estimated 40% of adults and 20% of children, according to federal data.

That could be especially valuable as many Americans continue to struggle with accessing next-generation weight loss drugs like Ozempic and Wegovy, due to barriers such as high costs and supply chain issues.
Unlike the M. vaccae shot, these medications work by mimicking a natural hormone in the body that signals to the brain you’re full, helping to curb your appetite.

Using bacteria as a vaccine to stop weight gain sounds like the beginning of a dark apocalyptic comedy

Have some discipline and self respect for your body and stop over eating shit junk food. It doesn't hurt to walk more either.

Bring back some Scott Steiner style bullying too


<Steiner01>
 
You dont see this as much where i'm from but one time I visited Utah, and when we drove up to some big wal mart, the amount of super fat people in those carts was shocking to me.
They be drinking those jugs of soda with flavored syrups instead of alcohol
 
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Using bacteria as a vaccine to stop weight gain sounds like the beginning of a dark apocalyptic comedy

Have some discipline and self respect for your body and stop over eating shit junk food. It doesn't hurt to walk more either.

Bring back some Scott Steiner style bullying too


<Steiner01>
I can't stop eating Toblerone!
 
not a vaccine
results in mice.

they were fed a 'western diet' protocol for mice, which in the control condition, led to a weight gain from 20 grams to about 36 grams over 70 days. weekly innoculation with the commensal microbe decreased taht weight gain to about 31 grams, roughly the same as the mice fed a standard diet.

the microbe of interest, mycobacterium vaccae, has been shown to have numerous benefits in animal models. afaik, no direct human trials yet. m. vaccae is an abundant soil microbe that feeds on dead/decaying organic matter. afaik, not a normally a major colonizer of either the mouse or human microbiota. interestingly, in some published results, heat-killed m. vaccae was sufficient to produce benefits, indicating the there are compounds in the microbe that are at least in part responsible for the benefits observed, rather than the benefits being derived primarily from live colonization with the bacterium.

indeed, a novel lipid from m vaccae was identified that has at least anti-inflammatory effects on mouse cells in vitro
 
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