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I would say heavy squats will just tax your CNS and body to a point it will impact your MMA training. I have seen it a lot on the BJJ mat. You should get all of your work from your MMA training, but for targeted leg work... you honestly should just pick movements that are directly targeting the muscles while being safe. Why load your spine to squat when you should be working on all the balance, coordination and specific strength in your drilling? If you think of it, a barbell loaded squat has little carryover to real fighting. I will get flamed for saying this... but the OPTIMAL way to work the quads and hams are leg curls and leg extensions. Aside from that just do body weight squats at various intensities... aka what you will be doing in your training and fighting.