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Lightning blasts have a way of disintegrating enemies. Look for a pile of dust instead of a body, you can still loot the dust for the items! I don't think the Companion quests become unavailable: you can still do them but some companions can die. Not the immortal NPCs like Aela but some low rank.
As for the Gauldur amulet, I don't recall all the details. Is that the one you find the first fragment in Saarthal? If that's the one, the quest is called Forbidden Legend and is plagued with multiple bugs. Most bugs are related to the amulet itself but there are more serious ones. If you can describe your situation with the most details possible, maybe I can help you. Just tell me how much fragments you have found yet, which ones are missing and where you still have to go. Don't forget to tell me exactly what's the bug: a door that won't open? A crash? A big lag?
Keep in mind that you should always make "hard saves" when you reach a crucial point or start an entire new quest. Don't do it for every fetch quest but something like Forbidden Legend is a good example. If you keep a hard save before picking up the first fragment, most bugs are reversible. If you don't, you may have to backtrack a long way to find a viable save...
Hey cool ya it just says everything is done but the mission won't clear