Cain completely dominated JDS in the second fight (50-43 on one official scorecard) and presumably dominated him again in their third fight - but since he got the finish in Round 5, I wasn't able to find any round-by-round scoring for that one.
So yes, when you knock a guy out in a minute, then he comes back to completely obliterate you for 48 minutes straight, I think we can call that a fluke.