Sure Jones can lose, anyone can lose.
Jones is going to break all of the haters hearts. I'm a Jon Jones hater, but I have accepted the reality that despite me wanting to see him be the victim of an epic beatdown, he's going to continue to destroy people. Sure he might lose one or two here or there, but ultimately, he will hold that LHW strap until he can't cut the weight anymore, then he will move up and start humiliating the HWs until he gets himself in the position to take that strap too.
The butthurt around here will be HUGE, but I despite being a hater, have learned to accept the fact so I don't have to deal with the dissapointment.