the clinton foundation uses 89% of revenue for program costs - including charitable initiatives as well as employee costs, pensions, overhead etc. -- this is pretty standard among most charities and they get good grades. We do not know the effectiveness of their programs but that is not something that gets held against the financial merits of a foundation -- they get an A rating.
The concern is apparent connections with forigen and domestic donations and ties to the Clintons -- especially while Hillary was SS. There were some issues that raised concerns: uranium deals, telecom deals and other business lobbying and tie to them donating. Also, when Hillary became SS some practices that the foundation were previously open about became closed. Not releasing donor lists while she was SS (even though she promised they would), failure to report millions on time - or at all until questioned -- the exponential increase in Bills speaking engagements to donors during hillary's time as secretary.
Now there may be no evidence of wrong doing, however there is enough questionable smoke to cause a deeper investigation. At the very least, there were bad judgement on her part with various incidences. It also questions the Clintons ability to not use their position to leverage private deals and favoritism.