Definitely. I wouldn't be surprised if he outwrestled Brunson, his striking is exponentially better and his cardio is infinitely better (Brunson ALWAYS gasses late in round 2 or in round 3, it's amazing). Derek Brunson is the definitive gatekeeper, Vettori skipped over the mandatory Derek Brunson test but I have no doubt he'd pass it (and he has already beaten someone higher ranked).
No, the main things that hold him back are cardio and skills. I can only think of one fight where fight IQ cost him, and it was the Whittaker fight. Brunson is the definitive gatekeeper - always top 10, but never good enough to get a title shot. Anyone who beats him fights for the title. He always gasses late in round 2 or in round 3, and his chin-up striking style with his lacking fundamentals combined with his poor cardio will never allow him to beat top guys.