Why can't we make nonaddictive painkilllers?

[Lord Coke]

Hi Sherdog

I've got a question I'd like answered from a tech/medical point. I keep reading about the opoid problem in this country and I would like to know why can't we make something that is not physically addictive that still kills pain. What is the hold up. I understand their will always be a mental aspect but you'd think thy could fix the physical side of it.

 

[Bloody Pulp]

And what's the deal with cancer? I mean come on.

 

[Cubo de Sangre]

Kill's pain on what level to what degree? Aspirin not good enough? Weed has reduced opioid deaths in states when introduced as an option. Is that where we're going here? Outside of that I think I've heard of severing nerves.

Shit man, who doesn't like having pain killed? Sorta seems obvious by definition.

 

[InternetHero]

I think it is akin to why we can not make a coffee or tea that is not addictive or a pain medication that does not lessen in effect with use.

The mind adjusts to outside forces and stimulus.

 

[JDragon]

I think it is akin to why we can not make a coffee or tea that is not addictive or a pain medication that does not lessen in effect with use.

The mind adjusts to outside forces and stimulus.

Pretty good answer.

Also:

Spoiler

Why can't we make a non-addictive political discussion subforum on MMA boards?

 

[DragRacer]

CBD oil.

 

[Lord Coke]

I hear what you guys are saying but opoids have some very clear addictive properties separate from its ability to numb pain.

 

[Madmick]

I hear what you guys are saying but opoids have some very clear addictive properties separate from its ability to numb pain.

It doesn't numb the pain. It dissociates the pain signal. The very mechanism by which it works is that which ultimately induces both physical and psychological addiction. The baby and the bathwater are a single organism, here.

That's why.

 

[Anung Un Rama]

Hi Sherdog

I've got a question I'd like answered from a tech/medical point. I keep reading about the opoid problem in this country and I would like to know why can't we make something that is not physically addictive that still kills pain. What is the hold up. I understand their will always be a mental aspect but you'd think thy could fix the physical side of it.

https://www.google.com/amp/amp.live...-like-pain-relief-without-addiction-risk.html

 

[Clippy]

We need milk of the poppy

 

[Madmick]

https://www.google.com/amp/amp.live...-like-pain-relief-without-addiction-risk.html

Brilliant. A second drug to selectively dissociate the undesirable dissociation of the first drug.

Fuck me, scientists are smart. I guess that's why the average life of an American in 2017 is 79 years of age when in the year 1900 it was 47. Pneumonia was the #1 killer. But it totally makes sense when all these anti-Vaxxers and other ignoramuses cry out, "The pharmaceutical industry is killing us! The FDA is killing us!" Piss off, caveman. Go sit in a corner and read your Mercola book.

Certainly the FDA has its problems, but it didn't exist in 1900, and it seems we were far more talented at dying without them.

 

[Anung Un Rama]

Brilliant. A second drug to selectively dissociate the undesirable dissociation of the first drug.

Fuck me, scientists are smart. I guess that's why the average life of an American in 2017 is 79 years of age when in the year 1900 it was 47. Pneumonia was the #1 killer. But it totally makes sense when all these anti-Vaxxers and other ignoramuses cry out, "The pharmaceutical industry is killing us! The FDA is killing us!" Piss off, caveman. Go sit in a corner and read your Mercola book.

Certainly the FDA has its problems, but it didn't exist in 1900, and it seems we were far more talented at dying without them.

It's difficult to separate the scientific brilliance of pharmacology from the capitalistic nature of Big Pharma for the gen pop. Anti Antivaxxers are the unhinged radical wing of the frustrated masses, bu cynicism is not unwarranted.

 

[Dayman1984]

I remember reading somewhere about research being done on sea snail venom. They wanted to try and tease out the analgesic compounds and leave the illness/death causing compounds out (of course ). Would be pretty amazing if there was a very powerful, non addictive pain killer created.

 

[oldshadow]

Well we can go forward and it may take a while to come up with what you ask other then a spinal block.

Or we can go back to the good old days and a stick to bite on.

 

[Renard]

The problem aren't the drugs themselves, it's the fact they're over-prescribed. The US consumes massive quantities of painkillers compared to other western countries, where doctors prescribe them only when absolutely necessary.

 

[superpunch]

In Star Trek they had managed to engineer alcohol that doesn't get you hung over and doesn't damage your body. So we'll get the nonaddictive heroin around when they invent the warp drive.

 

[superpunch]

I think it is akin to why we can not make a coffee or tea that is not addictive or a pain medication that does not lessen in effect with use.

The mind adjusts to outside forces and stimulus.

And the inability to adapt is what causes CTE in some athletes. It has to do with a specific gene that controls how your brain rewires itself after brain damage.

Most people have the normal phenotype and eat like hundreds of shots for a decade or two and be just as smart as Dominick Cruz.

Other people, like 20% of people, have the mutated gene and start showing brain damage after getting knocked out just once or twice. Mr. Potato Head is one of these people.

 

[MadSquabbles500]

Hi Sherdog

I've got a question I'd like answered from a tech/medical point. I keep reading about the opoid problem in this country and I would like to know why can't we make something that is not physically addictive that still kills pain. What is the hold up. I understand their will always be a mental aspect but you'd think thy could fix the physical side of it.

If you arent addicted and dont want to keep taking more and more, then they cant sell you more and more, and make more money.

 

[Rod1]

I think it would be easier to come up with a good recovery program to get people off drugs, but whats the profit on that?

 

[helltoupee]

Hi Sherdog

I've got a question I'd like answered from a tech/medical point. I keep reading about the opoid problem in this country and I would like to know why can't we make something that is not physically addictive that still kills pain. What is the hold up. I understand their will always be a mental aspect but you'd think thy could fix the physical side of it.

Because there are opioid receptors throughout your body which cause physical dependence. When you take a painkiller, it binds to receptors in the brain as well as the body, and cannot distinguish the difference.

You have a blood brain barrier that can stop the opposite from happening.

Such as with the opioid loperamide, which only binds to receptors in the body, but is prevented from entering the brain by P-Glycoprotein, and thus does not cause mental effects. This is why you can take Immodium, which contains the potent opioid loperamide, and not feel high.

However it does not work in reverse.