So, this is a bit niche but I think some people might be interested in hopping on at Episode 1 which just came out.
This guy ran both FO3 and FONV plus all DLC on just one health bar. Any damage stays damage. FONV ended up especially gripping as he was down to very little at the end of Lonesome Road. FO3 was probably harder due to more randomness but the Ghoul Mask plus Stealth Armor makes it very doable if you can get to them before taking too much damage.
Well, now he's doing, somehow, Fallout 4, on one health bar (using one mod to remove all healing). On Survival. The one with rad storms. And scorpion surprise rape and suicide nuke bombers. And overall, just much more challenging combat. This is very much a step up, and since he's one of my favorite YTers, thought I'd share the mad nerdy lad's thang: