Yep, cipralex for depression and anxiety, first week I was not able to orgasm at all, then in the months following, it would be very hard to achieve, and my sex-drive was about four times lower than usual.Did Your's affect your libido? If so, that's really unfortunate. I'm Bipolar 2 & I'm on Effexor & Abilify & fortunately, the combo doesn't have any adverse effects whatsoever. Especially to my libido. The only med that I have any experience with that had a negative effect on my sex drive was Zoloft. And I was only on it for a short amount of time.