I really think his best chance is to catch Nate behind the ear or something, disorientate the fuck out of him and win by early stoppage. Or win by headkick like Thomson did maybe. I really don't think that leg kick strategy people are throwing around will work. It will be retardedly difficult to outlast Nate and Conor showed he can't take Nate's strikes as reliably as Nate can take his. Nate would eventually land within 5 rounds.
As far as RDA vs Conor, RDA can last longer in Conor's world than vice versa. Conor could've KO'd him but RDA also could've taken him down and skullfucked him on the ground.