International [British COVID Vaccine News] GAVI Says Demand Still Strong For India-made AstraZeneca Vaccine

Evidence?
It's all over the internet. Covid 19 was extracted from a horseshoe bat along with being mixed with another virus. Doing so split the protein spur down the middle. It's genetically altered. The Wuhan lab is about a secure as a dentists office. This all is extremely disturbing.

Also look at country's that have malaria problems. They're having very little Covid deaths because they're already taking Hydroxychloroquin. Same goes for a lot of people with COPD. Doctors use Hydroxychloroquine as a part of the treatment of COPD.

At the very least this should raise an eyebrow or two. Don't believe me, do your own research.
 
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Why are they taking this cavalier approach? Is this Dana being Dana or what? It would be practically unlikely to prove, but how can they exempt themselves from liability from someone else catching covid from an attendee?

Has a company ever been sued because someone caught a virus off another customer? Can I sue Wal-Mart if I get the flu?
 
Has a company ever been sued because someone caught a virus off another customer? Can I sue Wal-Mart if I get the flu?

I cant think that its ever happened, but with all of the covid genetic sequencing, I would imagine its scientifically possible to prove with this virus, but practically very unlikely that this would be done for the UFC. It should have been obvious to the UFC when they drafted this disclaimer though that attendees could pass on their infection to others who were not in attendance and who have not agreed to accept this risk. I just dont understand why they seem to be actively discarding all the usual precautions.
 
Those images leave out a very relevant piece of information. 0.8 admissions per 16 weeks but the vast majority of those ICU admissions are people with underlying conditions, not healthy young people. For healthy young people the risk from covid is miniscule so there is a fair argument why a young and healthy person might decide not to take the vaccine.
 
I cant think that its ever happened, but with all of the covid genetic sequencing, I would imagine its scientifically possible to prove with this virus, but practically very unlikely that this would be done for the UFC. It should have been obvious to the UFC when they drafted this disclaimer though that attendees could pass on their infection to others who were not in attendance and who have not agreed to accept this risk. I just dont understand why they seem to be actively discarding all the usual precautions.


Because believe it or not, lots of people would like a return to normality. Removing the precautions is a return to normality. These types of events are essentially live action experiments to see just how things work once the precautions are removed, albeit the UFC went a step further than the UK test events. Wearing masks and social distancing is not normality, mate. Never has been. If we want to return to normality, or close enough, those things need to go eventually so lets test the water.
 
I cant think that its ever happened, but with all of the covid genetic sequencing, I would imagine its scientifically possible to prove with this virus, but practically very unlikely that this would be done for the UFC. It should have been obvious to the UFC when they drafted this disclaimer though that attendees could pass on their infection to others who were not in attendance and who have not agreed to accept this risk. I just dont understand why they seem to be actively discarding all the usual precautions.

If someone catches Covid outside the UFC, how is that the UFC's fault? If that person is wearing a mask, social distancing, and vaccinated, their chances of catching Covid is zero.
 
Because believe it or not, lots of people would like a return to normality. Removing the precautions is a return to normality. These types of events are essentially live action experiments to see just how things work once the precautions are removed, albeit the UFC went a step further than the UK test events. Wearing masks and social distancing is not normality, mate. Never has been. If we want to return to normality, or close enough, those things need to go eventually so lets test the water.

The way that football in England is doing it, as far as I know, is that youre supposed to be tested before and after, and the experiment with that is to see if holding a fan-attended football match would lead to a significant rise in infections. Of course things need to return to normal eventually, but i dont think we are at that stage yet.
 
This time next year, no developed country have any more excuses if they are still unable to produce any vaccine at home.



India has put their AstraZeneca vaccine distribution to other countries on hold as the country battles the world’s fastest-growing Covid-19 surge. The delay in distribution is hampering the global vaccination effort.
 
Good news for those who were wondering about mix and matching booster shots later down the road if necessary:

Spanish study finds AstraZeneca vaccine followed by Pfizer dose is safe and effective
May 18, 2021​

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A Spanish study on mixing COVID-19 vaccines has found that giving a dose of Pfizer's drug to people who already received a first shot of AstraZeneca vaccine is highly safe and effective, preliminary results showed on Tuesday.

The Combivacs study, run by Spain's state-backed Carlos III Health Institute, found the presence of IgG antibodies in the bloodstream was between 30 and 40 times higher in people who got the follow-up Pfizer shot than in a control group who only received one AstraZeneca dose.

Meanwhile, the presence of neutralising antibodies rose sevenfold after a Pfizer dose, significantly more than the doubling effect observed after a second AstraZeneca shot.

Around 670 volunteers between the ages of 18-59 who had already received a first dose of AstraZeneca's vaccine participated in the study, with some 450 given a Pfizer dose.

Just 1.7% of the participants reported severe side effects, which were limited to headaches, muscle pain and general malaise, said Dr Magdalena Campins, one of the study's leaders.

"These are not symptoms that can be considered serious," she said.

In a U.K. "mix-and-match" study, first findings recently showed that people vaccinated with a shot of Pfizer's vaccine followed by a dose of AstraZeneca's, or vice versa, were more likely to report mild or moderate symptoms such as headaches or chills than if they received two of the same type. Data on immune responses are expected in the coming months. read more

Spain embarked on the study to determine how best to proceed after limiting AstraZeneca's shot to people aged over 60 due to concerns about blood clotting in younger people.

That restriction caused widespread uncertainty and meant some younger people who had already received a first dose have been excluded from getting a second.

"Today's results support the possibility of vaccinating patients who have received the first dose from AstraZeneca, but the decision is not up to the investigators of this study," said Jesus Antonio Frias, clinical director at Carlos III.

https://www.reuters.com/business/he...e-followed-by-pfizer-dose-is-safe-2021-05-18/
 
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Malawi destroys 20,000 expired doses of AstraZeneca vaccine
GREGORY GONDWE | May 19, 2021

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Blantyre, Malawi (AP) — Malawi has burned nearly 20,000 expired AstraZeneca vaccines, amid conflicting advice over what to do with the doses.

Health Minister Khumbize Kandodo Chiponda put some of the vials of the expired doses into an incinerator to start the destruction Wednesday at Kamuzu Central Hospital in Lilongwe, the capital.

“We are destroying (these vaccines) because as government policy no expired health commodities are to be used,” she said. “Historically under the expanded immunization program of Malawi no expired vaccine has ever been used.”

She said burning the vaccines will build public confidence that all vaccines used in Malawi are good.

“We are destroying publicly in order to stay accountable to Malawians. The vaccines that expired are not being used during the vaccination campaign," she said. "On behalf of the government, I assure all Malawians that no one will be given an expired COVID vaccine.”

The burned vaccines were the remainder of 102,000 doses that arrived in Malawi on March 26 with just 18 days until they expired on April 13. All other doses of the shipment, donated by the African Union, were successfully administered, she said.

The health minister thanked WHO, the African Union and India for donating the vaccines.

“This has made it possible for Malawi to embark on the COVID vaccination campaign currently underway,” she said.

Last month the World Health Organization urged African nations not to destroy expired doses of the AstraZeneca vaccine after several countries received doses from India with a very short shelf life. But this week, WHO reversed its position and said that the vaccines should be destroyed.

“Any vaccine that has passed its expiry date ... should not be administered,” said WHO in a statement dated May 17. “While discarding vaccines is deeply regrettable in the context of any immunization program, WHO recommends that these expired doses should be removed from the distribution chain and safely disposed.”

WHO said that in March, the African Union’s African Vaccine Acquisition Task Team redistributed 925,000 doses of the AstraZeneca vaccine produced by the Serum Institute of India with an expiry date of April 13 to 13 African countries. “The bulk of these vaccine doses were administered, but some countries have unused doses remaining,” said the WHO statement.

Malawi, a small southern African country of about 20 million people, had already decided to destroy its expired vaccine doses, ministry of health spokesman Joshua Malango told The Associated Press.

“We had stopped observation of proper storage mechanisms and the vaccines would have still been damaged in one way or the other,” he said.

The destruction of the vaccines was witnessed by several top officials "in order to enhance transparency,” health secretary Charles Mwansambo said.

Malawi will still have adequate stocks of COVID-19 vaccines in both public and private health facilities, he said. The government has not said where it will get more vaccines.

Malawi's got its first consignment of 360,000 AstraZeneca doses in early March from the U.N.-backed COVAX initiative which is providing vaccines to low- and middle-income countries. The country received another batch of 50,000 AstraZeneca doses from the Indian government. With the AU donation, Malawi had a total of 512,000 AstraZeneca doses.

So far 212,615 doses have been given in Malawi. The country has 34,216 confirmed cases, including 1,153 deaths, according to the Africa CDC.

Currently, the country is seeing a decrease in the disease, with the 7-day rolling average of daily new cases in Malawi dropping from 0.07 new cases per 100,000 people on May 4 to 0.04 new cases per 100,000 people on May 18. Official deaths from COVID-19 are also declining, according to statistics from Johns Hopkins University.

Malawi, like many other African countries, has relied on the AstraZeneca vaccine that has been distributed by COVAX and the African Union. But now supplies of the vaccine have become more scarce because India, the main supplier of vaccines to COVAX, has stopped exports until it has adequately vaccinated large numbers of its population of 1.4 billion people.

The Serum Institute of India says it hopes to start delivering coronavirus vaccines to COVAX and to other countries by the end of the year. The delay will significantly set back global efforts to immunize people against COVID-19. India’s Serum Institute is the world’s biggest vaccine-maker. The company said in March that it was postponing all exports of coronavirus vaccines to deal with the explosive surge of cases on the subcontinent. At the time, the World Health Organization said it expected COVID-19 vaccine deliveries from India to resume by June and the interruption would affect about 90 million doses.

https://news.yahoo.com/malawi-burns-20-000-astrazeneca-104629671.html
 
Good. First shot I got was AZ and second was Moderna. Had even worse fever and muscle and joint ache after the second one that lasted for just over half a day.

Would be cool if they keep track of the efficacy for this mix & match. I'm guessing it would be around 80%.
 
No thanks. If I'm offered AZ instead of my second Pfizer, I'll be walking away and telling them to call me back in a few weeks. I'm not being even more of a guinea pig than I already am.
 
Two doses of the AstraZeneca shot were shown to be 60% effective against the Delta strain, according to NIH data. One dose only gets you 33%, so get that second shot in!

What to know about the delta COVID-19 variant first detected in India
Getting your second vaccine dose is especially important for this variant.



The delta variant, which was first detected in India and which now makes up 6% of sequenced COVID-19 cases in the United States, has prompted recent calls from President Joe Biden and Dr. Anthony Fauci for more Americans to get vaccinated.

While prevalence of the variant, also known as B.1.617.2, is still low in the U.S., its prevalence has doubled since last week, rising from 3% to 6%, according to a report from HHS.

In India, where the virus exploded in April and May and sparked a public health crisis, as well as in the United Kingdom, the delta variant is now the dominant strain. "We cannot let that happen in the United States," Fauci said during a Tuesday news briefing.

"Get vaccinated," he added. "Particularly if you’ve had your first dose, make sure you get that second dose. And for those who have been not vaccinated yet, please get vaccinated."

Are vaccines effective against the delta variant?


Yes and for those who got the Pfizer or Moderna vaccine, it's important to complete the two-shot regimen.

A study the British government conducted in April and May, which analyzed more than 12,000 sequenced COVID cases, found Pfizer and AstraZeneca vaccines to be highly effective against the delta variant, although efficacy was lower for the delta variant than for the alpha variant of the virus.

According to the study, Pfizer vaccine was 88% effective against symptomatic disease two weeks after the second dose and the AstraZeneca vaccine was 60% effective two weeks after the second dose.

"For those properly vaccinated, it looks like there isn't an issue," Krogan said.

But for people who only received one dose of the vaccine, "effectiveness was notably lower," the study authors note. Both the Pfizer and AstraZeneca vaccines were about 33% effective against the delta variant after one dose.

"There’s poor protection after a single dose," Fauci said on Tuesday, and stressed the important of getting the second shot for the two-dose vaccines.

As for the mechanism driving double-dose protection, Racaniello thinks the world has focused too much attention on spike protein mutations and antibody response, and not enough on T-cells, another part of the immune system which also defends the body against infection. "I don't care if you've got alpha, beta, gamma or delta, those T-cells are still going to be able to prevent serious disease and those T-cells are made by vaccination," he said.

Vaccination is also the key to stopping the virus from circulating and more variants from popping up, according to experts. The longer it takes to get the country and the world vaccinated the more chances the virus has to mutate.

"We're going to be dealing with these other variants in the future that the vaccines may or may not be able to control," Krogan warned. In his view, it's not time to be complacent. "We've got to get everybody vaccinated, but we need to understand how these viruses are mutating and overcoming our defense mechanisms," he said. "The virus has always been a couple of steps ahead of us. We've got to get a step ahead of it."

https://abcnews.go.com/amp/Health/delta-covid-19-variant-detected-india/story?id=78197319
 
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Ontario stands firm on 12-week interval for AstraZeneca doses
Gap between vaccine doses is only 8 weeks in other Canadian provinces
By Nicole Ireland | June 10, 2021

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Citing the need for speed against the growing threat of the coronavirus delta variant, infectious diseases specialists say they disagree with the Ontario government's decision to maintain a 12-week waiting period before people who received a first dose of the AstraZeneca-Oxford vaccine can get their second dose.

That rule applies even for people who got a first shot of AstraZeneca and are choosing an mRNA vaccine (Pfizer-BioNTech or Moderna) for their second.

In contrast, people in Ontario who received an mRNA vaccine as their first dose can get their second one after just eight weeks.

Other provinces, including B.C., Alberta and Quebec, are now recommending that everyone get their second dose after eight weeks, regardless of whether the first jab was AstraZeneca or an mRNA vaccine.

Speed vital to counter delta variant
Infectious disease experts widely agree that the two doses required to be fully vaccinated against coronavirus will offer stronger protection against the delta variant of the virus, which has become the dominant strain in the U.K. and is gaining momentum in Canada.

"The push should really be to get those second doses in fast," said Dr. Isaac Bogoch, an infectious disease specialist at Toronto General Hospital, who is also a member of Ontario's COVID-19 Vaccine Distribution Task Force.

"Treat a crisis like a crisis," Bogoch said. "Even though case numbers are declining and hospitals are decompressing and vaccines are rolling out — and clearly that's all good — you still have a delta variant. You still are watching this encroach on the existing variants here.

"You also have a crystal ball. You can look at the United Kingdom and see exactly what's happening there," he said. "This variant will find unvaccinated people and it will find undervaccinated communities. It's doing that in the U.K. and it will do the exact same thing here with us."

Getting not only first doses but also second doses into arms as quickly as possible after the four-week mark (which experts agree is the minimum interval for effectiveness) is vital to stopping that from happening, Bogoch said.

But in an email to CBC News on Thursday, Ontario's ministry of health said its decision is driven by scientific data.

"We know that two doses of AstraZeneca at a 12-week interval provides a better immune response than over a shorter interval," the ministry said.

The 12-week interval for people who got the AstraZeneca shot will still apply in delta variant "hotspots," the ministry confirmed to reporters later — even as it starts a program to accelerate second shots for people who got mRNA vaccines in those areas.

Dr. Dirk Huyer, Ontario's chief coroner and another member of the province's vaccine task force, also defended the 12-week duration between doses, noting that the move is based "upon the data that's available."

There isn't much information yet, Huyer said, about the optimal timeframe between a first dose of AstraZeneca and a second dose of either Pfizer-BioNTech or Moderna.

"We will continue to look at everything that's available to us," he said.

Later on Thursday, Dr. Barbara Yaffe, Ontario's associate chief medical officer of health, told reporters that officials would continue to look for more guidance on how to space out mixed doses for people who got a first shot of AstraZeneca but want their second shot to be an mRNA vaccine.

It's true that randomized control trials have shown two doses of AstraZeneca generate the optimal immune response if they are 12 weeks apart, said Dr. Caroline Quach-Thanh, pediatric infectious disease specialist and medical microbiologist at Chu Ste. Justine in Montreal.

But there's no evidence that's the case when people choose an mRNA vaccine instead of AstraZeneca as their second dose, she said.

"You don't need to wait 12 weeks," said Quach-Thanh, who is the former chair of the National Advisory Committee on Immunization (NACI), but was not speaking on NACI's behalf.

https://www.cbc.ca/amp/1.6060848
 
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New hospitalization numbers from the Delta variant in England are still small enough to be manageable by the British healthcare system, while there's no spike in Wales, Scotland, and Northern Ireland.

Wonder what Boris will do as the June 21 reopening day is quickly approaching. Surely doctors will push for a delay so more people can get their 2nd dose, but that would be very bad PR for the much-touted reopening.
Unvaccinated most at risk from Delta variant
By Philippa Roxby | June 11, 2021

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Nearly two-thirds of people infected with the Delta variant, and more than half of those who have died with it, have not had a Covid vaccine at all, the latest official data suggests.

There have been nearly 30,000 new UK cases of the variant in the past week.

The Public Health England report says it is likely to spread more easily and could make people more seriously ill.

Officials also say two doses of the vaccine provide "significantly more protection" than one.

It comes as the Office for National Statistics estimates coronavirus infections are continuing to rise in England, with one in 560 people testing positive.

But the ONS found no obvious increase in infections in Wales, Scotland and Northern Ireland.

The Delta variant, which was first identified in India, is now the dominant variant in the UK - accounting for 90% of cases.

It is being closely monitored by PHE, which is using new genotyping tests to detect the variant more quickly as cases continue to rise.

These suggest that the Delta variant is roughly 60% more spreadable than the Alpha, or Kent, variant.

Analysis of hospital admission rates suggests people infected by the Delta variant are twice as likely to end up in hospital than those with Alpha.

The numbers are still small, however.

Out of 33,000 cases analysed by PHE and confirmed to be the Delta variant since February, 223 have been admitted to hospital - most were unvaccinated or had only had only dose, and 20 people were fully vaccinated.

And of 42 deaths in people with Delta variant infections, 23 were unvaccinated and seven had received only one dose. The other 12 had received two doses more than two weeks before.

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In the UK, more than half of all adults have now been fully vaccinated with a Covid vaccine and more than three-quarters have had one dose. But that means more than 10 million adults, mostly in their 20s, have yet to have a single dose.

As more young people are vaccinated, protection against the new variant will rise.

Dr Jenny Harries, chief executive of the UK Health Security Agency, said "vaccination is our best defence".

"If you are eligible, we urge you to come forward and be vaccinated. Remember that two doses provide significantly more protection than a single dose."

However, Dr Harries warned that while vaccination reduces the risk of severe disease, it does not eliminate it because Delta is "significantly more transmissible than Alpha".

Prof Adam Finn, a member of the UK's Joint Committee on Vaccination and Immunisation, told the BBC the current wave of infections was increasing "faster than we hoped", but the vaccines "do still work".

"The more population immunity we've got, the smaller this wave will be," he added.

Meanwhile, the latest R number - or reproduction number - in England is estimated to have risen to between 1.2 and 1.4, up from between 1 and 1.2 last week, according to the government's Scientific Advisory Group for Emergencies.

If the R number is above one, then the number of cases keeps increasing.
https://www.bbc.com/news/health-57441677.amp
 
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Unvaccinated most at risk from Delta variant
By Philippa Roxby | June 11, 2021

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https://www.bbc.com/news/health-57441677.amp

So both vaccinated and unvaccinated people people are at risk of death from the Delta variant. And of 42 deaths in people with Delta variant infections, 23 were unvaccinated and seven had received only one dose. The other 12 had received two doses more than two weeks before.

Both vaccinated and unvaccinated people are at risk of hospitalisation, albeit a very small amount considering 33K cases, only 223 hospitalisations, of which only one dose or not vaccinated, 20 fully vaccinated.
Sounds like the AZ vaccine isn't performing that well against the delta variant looking at the death tally from delta.




 
Got my 2nd jab this Friday night, Pfizer again I fucking hope or I'm walking out and going home. Hoping I can get it before they start enforcing this 'mix and match' bollocks on the population going forward.
 
So both vaccinated and unvaccinated people people are at risk of death from the Delta variant. And of 42 deaths in people with Delta variant infections, 23 were unvaccinated and seven had received only one dose. The other 12 had received two doses more than two weeks before.

Both vaccinated and unvaccinated people are at risk of hospitalisation, albeit a very small amount considering 33K cases, only 223 hospitalisations, of which only one dose or not vaccinated, 20 fully vaccinated.
Sounds like the AZ vaccine isn't performing that well against the delta variant looking at the death tally from delta.




As the Delta variant has just recently arrived in Europe from India, both the hospitalization and deaths sample sizes are too small to be statistically meaningful. Give it a few more months and the picture should be clearer by the time Delta supplants Alpha in the U.S.

What we do know now is traditional vector vaccines like AZ are not very good against new variants, its efficacy against Delta is only 30% for first dose and 60% for second dose, while a full course of the mRNA vaccines provide 88% protection.

I wouldn't be surprised if more European nations will offer a Pfizer-BioNTech booster for people who had an AZ first dose in a bid to increase their antibodies counts (much like what the Middle East is doing for their people who had the 50%-effective Chinese vaccine).
 
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