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I think we should worry more about 38-40 year olds that Are still competitive in the top 20, or HWs or LHWs that go full speed for 5 rds...
But your question is interesting.
When it was announced in february 2015 that the UFC partnered with USADA, we had some very strong champions. Very few saw them losing in the near future, And they looked nearly unbeatable. Then USADA came:
Ironically one of the only 2 champions still champ at the end of the year is the only one on that list of champions who actually has been caught by USADA in Dillashaw.
EDIT. Apart from Jones.