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Main Card (PPV)
Daniel Cormier (21-1) vs. Derrick Lewis (21-5) (Heavyweight Championship)
Chris Weidman (14-3) vs. Ronaldo Souza (25-6) (Middleweight)
David Branch (22-4) vs. Jared Cannonier (10-4) (Middleweight)
Karl Roberson (6-1) vs. Jack Marshman (22-7) (Middleweight)
Derek Brunson (18-6) vs. Israel Adesanya (14-0) (Middleweight)
Preliminary Card (Fox Sports 1)
Jason Knight (20-5) vs. Jordan Rinaldi (13-6) (Featherweight)
Sijara Eubanks (3-2) vs. Roxanne Modafferi (22-14) (Women's Flyweight)
Julio Arce (15-2) vs. Sheymon Moraes (10-2) (Featherweight)
Ben Saunders (22-10-2) vs. Lyman Good (19-4) (Welterweight)
Preliminary Card (UFC Fight Pass)
Matt Frevola (6-1) vs. Lando Vannata (9-3-1) (Lightweight)
Shane Burgos (10-1) vs. Kurt Holobaugh (17-5) (Featherweight)
Adam Wieczorek (10-1) vs. Marcos Rogerio de Lima (15-5-1) (Heavyweight)
Other
- A bantamweight bout between Brian Kelleher and Domingo Pilarte was expected to take place at the event. However on October 10, it was reported that Pilarte pulled out due to injury and was replaced by Montel Jackson.
- Sultan Aliev was expected to face Lyman Good at the event, but he pulled out due to injury. He was replaced by Ben Saunders on October 19.
- A middleweight bout between former UFC Middleweight Champions Luke Rockhold (also former Strikeforce Middleweight Champion) and Chris Weidman was expected to take place at the event. The two previously met at UFC 194 where Rockhold defeated then champion Weidman with a fourth round knockout. However, Rockhold pulled out on October 19 due to multiple injuries. He was replaced by another former Strikeforce champion Ronaldo Souza, who was initially scheduled to face former WSOF Middleweight and Light Heavyweight Champion David Branch in the event. Branch will now face Jared Cannonier as of October 19.
- Ruslan Magomedov was expected to face Marcos Rogerio de Lima at the event. However on October 24, it was reported that he pulled out of the event due to visa issues and was replaced by Adam Wieczorek on October 24.
- At the weigh-ins, Sijara Eubanks and Brian Kelleher both missed the required weight for their respective fights. Eubanks weighed in at 127.2 pounds, 1.2 pound over the flyweight non-title fight limit of 126. Meanwhile, Kelleher weighed in at 137 pounds, 1 pounds over the bantamweight non-title fight limit of 136. Both Eubanks and Kelleher were fined 20 percent of their purse, which went to their opponent Roxanne Modafferi and Montel Jackson. The Kelleher and Jackson bout was cancelled the day of the event as Kelleher was pulled due to illness.
