I'm favoring Luque due to a granite chin, powerful albeit technical striking, killer instinct, and nonstop pressure. But I agree with a few others that Tyron has a nonzero chance of pulling something off here and I say this as a fan of Luque who wants to see T-Wood hang 'em up. Vicente is there to be hit at times, especially when he's on the attack and also has questionable defensive grappling, whether it's being pushed against the cage, taken down, or being submitted earlier in his career.
Again, I'm for Vicente here but part of me can't help but picture him getting the Darren Till treatment and I hate myself for it. After doing well in the initial exchanges he comes in a bit reckless, gets caught clean with a right hand and rocked badly -- maybe it drops him outright, or maybe Tyron hits him with a blast double afterward to take it to the ground. Cue a frantic ground exchange in which a compromised Luque gets chocked the fuck out.
Other than that, though, I like Vicente by lopsided Decision or late TKO.