Tbol have the longest half life of any substance?

[Harmonica]

So according to the tests, Jon Jones had More turinabol in his system Fight night than he did in that dec 10 failed test?

How?!

Adrenaline dump coupled with turinabol results in stronger-than-usual pulsing.

 

[DaWrassler007]

 

[Rea_ctor]

It was supposed to be deca but it seems there's a new/old king in town.... Bullshit haha

 

[Katsumi Yamada]

Is there any doubt jon jones is still juicing or could there really still be traces of this metabolite that where the same amounts 2 years ago as it is now?

I have never heard of any substance with a half life like this beside maybe uranium?

In 2017 it was 20 picograms, in 2018 it was 60-80 picograms lol.

Whole thing is a joke.

 

[Fearthekhabib]

It doesn’t even Matter Jon was clearly abducted by aliens who inserted these long lasting chemicals into him which will be there for rest of his life and even when he’s dead, until the universe ends

 

[Harlekin]

Doesn't matter how long it lasts if Jones keeps taking it.

 

[Ravenwing]

Boyond bizare now t

 

[Leftie]

it's entirely possible

 

[JRubin]

Nah some pollutants that are super stable and not metabolised once they lodge in a fat cell and really like to stick to lipids can last for a long time. Some PCBs have a half life of more than a decade.

Based on general guidelines for how long a given molecule should be in the body and how readily metabolised, it makes sense M3 could last a while, but I don't think it should be decades. However you have to actually do the study to really know.

Correct me if I'm wrong


When Jon initially failed, it was his pre fight test where he weighed in at 205lbs.

At what point does it make sense that he would still be pulsing the same amount while weighing around 220-230lbs.

If it was stored in fat cells, than how would the TBol metabolite attach itself to fat lipids that didnt even exist at the time.

 

[JRubin]

dehydration from the weight cut pulls it out of his body. That's the theory, anyway.

He wasnt in a weight cut when he failed the July test for Tbol metabolite

 

[ralek4grammy]

Jon is like some kind of Radon girl (RIP). 1600 years later he'd still register on a Geiger counter and we'd be told it's normal. "Kids, look at the screen, here lies the great JBJ."

 

[ocean size]

Correct me if I'm wrong


When Jon initially failed, it was his pre fight test where he weighed in at 205lbs.

At what point does it make sense that he would still be pulsing the same amount while weighing around 220-230lbs.

If it was stored in fat cells, than how would the TBol metabolite attach itself to fat lipids that didnt even exist at the time.

Because when you gain fat, it isn't a perfect layer that covers the existing fat and locks it in until you lose that weight again. And the lipophilic metabolite, is likely to be in the adipose cell membranes which are made of lipids, floating from one to another so while there could be more in 'deep' tissue I'd expect it to make its way to newly deposited fat too.

All he need to do to have fat burning cause a 'pulse' is work out in a session and started burning a little fat in the slow oxidative muscle or metabolised it to replenish glycogen stores he's burned through.

It's all hypothetical but if the metabolite really is capable of 'pulsing' it is plausible to piss some in circumstances like that.

 

[ralek4grammy]

Something like that.

 

[Rvd Slmr]

The correct question is: what other metabolites of banned substances have similar lingering time-frames?

Or, how many of the numerous others athletes that failed for turinabol in the past had such lasting pulsing metabolites effect?

 

[MescalineDreams]

The half-life of a substance is not the same as the lasting duration of every metabolite of the substance. These are two different things. The half-life of a substance tells you its rate of decay, and can be used to determine the time frame within which it will be detectable as an integral molecular compound. A metabolite is a compound resulting from the metabolic process and chemical pathway to which the substance(s) is related, in this case the compound "M3", which is C26H35ClO9. It obtains when tbol is subject to Hydroxylation and Glucuronidation. Here's a helpful diagram of the chemical reaction-pathways for tbol and its metabolites:

View attachment 510821

Nobody is claiming the half-life of tbol is as that of its metabolites. That would be stupid, because different metabolites have different half lives, and these are different from the base substance. That's the entire point: M3 seems to behave thus unusually. You could ask a chemist why this metabolite in particular would be more resilient to decay.

The correct question is: what other metabolites of banned substances have similar lingering time-frames?

i like you

 

[krelianx]

Or, how many of the numerous others athletes that failed for turinabol in the past had such lasting pulsing metabolites effect?

Right.

 

[JRubin]

Because when you gain fat, it isn't a perfect layer that covers the existing fat and locks it in until you lose that weight again. And the lipophilic metabolite, is likely to be in the adipose cell membranes which are made of lipids, floating from one to another so while there could be more in 'deep' tissue I'd expect it to make its way to newly deposited fat too.

All he need to do to have fat burning cause a 'pulse' is work out in a session and started burning a little fat in the slow oxidative muscle or metabolised it to replenish glycogen stores he's burned through.

It's all hypothetical but if the metabolite really is capable of 'pulsing' it is plausible to piss some in circumstances like that.

Except your explanation would make the pulse producing greater or equivalent to previous levels more unlikely.

If the metabolite went from being 1/100 to being 1/1000 to then test for the same levels, numerous times, over a prolonged period of time seems a little far fetched.

 

[ocean size]

Except your explanation would make the pulse producing greater or equivalent to previous levels more unlikely.

If the metabolite went from being 1/100 to being 1/1000 to then test for the same levels, numerous times, over a prolonged period of time seems a little far fetched.

Yeah but there's no reason to think he's eliminated 90% of his body burden of the metabolite.

July 2017 original fail - 20-80 picograms
Aug 2017? I forget exactly when the next test was but it was negative
Year goes by
2018:
Aug. 9 (negative)
Aug. 29 (positive 8 picograms)
Sept. 18 (positive 19 picograms)
Sept. 21 (negative)
Oct. 2 (negative)
Oct. 11 (negative)
Nov. 14 (negative)
Dec. 9 (positive 60-80 picograms)
UFC 232- 33 picograms

So the first earlier were two small 'pulses' which is reasonable enough, the big fail is when he was in camp, and then fight night he had been rehydrating and eating and body probably wasn't in a catabolic state, but burning fat still would have mobilized some M3.

Not to mention being a little better or worse hydrated could probably make the difference between 20 and 80 pg.

If he hasn't lost too much of the total body burden of metabolite and his tissues are loaded to the gills with M3, it isn't that far fetched. If that's the case he should be pissing it for a good long time.

 

[Congo66]

The half-life of a substance is not the same as the lasting duration of every metabolite of the substance. These are two different things. The half-life of a substance tells you its rate of decay, and can be used to determine the time frame within which it will be detectable as an integral molecular compound. A metabolite is a compound resulting from the metabolic process and chemical pathway to which the substance(s) is related, in this case the compound "M3", which is C26H35ClO9. It obtains when tbol is subject to Hydroxylation and Glucuronidation. Here's a helpful diagram of the chemical reaction-pathways for tbol and its metabolites:

View attachment 510821

Nobody is claiming the half-life of tbol is identical to that of its metabolites. That would be nonsense, because different metabolites have different half lives, and these are different from the base substance. That's the entire point: M3 seems to behave thus unusually. You could ask a chemist why this metabolite in particular would be more resilient to decay.

The correct question is: what other metabolites of banned substances have similar lingering time-frames?

Half-life - radiation is the time is takes for radiation levels to half, irrelevant for this thread.
Half-life - the time taken for the concentration of a drug in the body to decrease by half.

The drug has done it's thing and has already gone from his system which is why they're testing for a metabolite as that's what's created when the drug interacts with your system.

Now the problem with the second one is testing. If you killed Jones and dissected him to test for the metabolite and then put him back together and then did it again a month later you'd be able to test whether the amount had reduced or not. As it's a piss test you're testing the concentration found in his piss and that's not the same thing. If you drink a load of water then the concentration of anything in your piss will be lower. If you accept that the metabolite is stored in his fatty tissue, released as that tissue is used and then it's going via the kidneys and into his piss it still doesn't tell you how much was in his body or how much is still remaining.

They should have kept him banned until he was testing clean though, then it wouldn't be an issue.

 

[Omega Man]

You morons really think Jones had an advantage in the fight from a metabolite?