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John Wang
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Six months after researchers in China bioengineered monkeys to have autism, a Japanese team of scientists has used the same technology to create monkeys with Parkinson’s. It’s a scientific first, and it could lead to effective treatments—but do the ends justify the means?
As reported in New Scientist, a team led by Hideyuki Okano from the Keio University School of Medicine in Tokyo has used genetic engineering to create a marmoset monkey with Parkinson’s disease. The researchers unveiled the monkeys last month at a meeting in Alpbach, Austria, and say they’ve also bioengineered monkeys to mimic Alzheimer’s disease and motor neurone disease. These monkeys are now three years old, and they’ve already started to exhibit the tell-tale signs of Parkinson’s.
In the three years since the engineered marmosets were born, they developed Parkinson’s symptoms in the same way people do. This began with signs of sleep disturbance in their first year, followed by the appearance of a-synuclein-associated globules, known as Lewy bodies, in their brain stems the next year.
By their third year, the monkeys began to show the characteristic tremors associated with the condition. As further evidence of how similar these monkeys are to humans with Parkinson’s, Okano showed that their tremors could be eased by giving them L-DOPA, a drug given to people with Parkinson’s to make up for the lack of dopamine.
Do you think Scientists are mean for doing this??
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