As long as your fat burner does not contain ephedra(ine) then there should be know interference with the NO, at least in terms of vasodilation issues. The real issue would be a potential overdose of non-ephedra stimulants, which will be in your fat burner and your xplode. Therefore, you would not want a full dose of each as this will be too much stimulant for most people. So, you could either cut the dose of each, which will limit the amount of caffine, but also limit the amount of creatine and NO from your xplode. So, just ditch the fat burner, and get the full dose of xplode and you'll be good to go. Now, for people who are stimulant sensitive, a full dose of xplode or a similar product is still way too much caffine (even without taking a fat burner) so it may be a better route to get a creatine and no separate, then consume just a little (if any) stimulant to get that 'surge' that we all know and love.