The Lo-Bloo cup can be used with any under-garment / boxer / short - so you won't have the direct skin contact and you are not dependent to any compression short. If you work out several times a day / week - you can wear it with anything and you don't have to worry about keeping one brand's short keep and dry all of the time. Safer and more hygienic: easy to rinse or just throw in the washer.
Also, it's "NOT" only for Strikers or Muay Thai - anyone in extreme sports can use it. Think of all of the nut shots we've seen with skateboarders, BMXer's, Stunt actors, etc...