Izzy is the better striker of the two.
Having said that his striking is not so clean as he can't get touched, look at the gastelum fight.
Adesanya will not have the huge luxury of a huge reach advantage like he as in almost every one of his fights.
Reach of notable fighters:
Whittaker 73
Romero 73
Gastelum 71
Costa 72
Brunson 77
Blachowicz 78
Adesanya 80
Credit to Adesanya for taking this fight, good chance he gets Ko'd, Jan has shown the ability to ko with just landing one good shot.
I predict Adesanya tries to avoid punching and sticks to leg kicks for most of this fight, he knows what happens if he gets tagged by Jan.