Yes. People will say no, and point to guys with small hands that have big power or guys with big hands and small power as evidence.
But physics is physics and those guys with small hands and big power would hit even harder of their hands were bigger, just as the guys with big hands and small power would have even less power if their hands were small.
More mass at the end of the striking object means more momentum. Period. That's why baseball bats get fatter at the end and taper at the handle. Hard to hit a home run with a broom stick or a two by four.
There's an upward limit, of course, because before you gather momentum you need to fight inertia and get the hand moving... but we're probably talking about a freakish and impossible 20-30 lb hand before that happens. Even an impossible 10 lb hand, while it would take a bit to get going, would deliver a wicked KO blow at the end of the arm of a professional fighter.
Most of the world understands these things and has for most of history. That's why ancient clubs have balls at the end and modern gun makers market larger caliber guns that are harder to use, but worth it for their increased stopping power.
But all of that is ignored around here because somebody once heard of someone being killed with a .22 and someone else getting shot with a .44 and walking away.
Sherdog gonna Sherdog.