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Wasn't there some Roman emperor with brain damage from lead that burned down some libraries and books?
Hard to say, a lot of ancient history boils down to people being either insane zealots, military geniuses, or scientific/artistic innovators.
It was apparently the muslim conquest in like 640ad that finally destroyed what was left of the pyramids.
Julius Caesar was runored to have caused a major fire when in retreat, decided to torch his fleet.
Shame though, what information that survived probably could have progressed the world a lot earlier