I think he has a great chance of running over Reem and Stipe, but JDS is such a good foil for so many styles that we always make him the favourite in every fight but vs Cain. He can be KO'd too, we've seen that.
Oh he has great power if he lands cleans on any of them Cain, Reem, Stipe they are most likely down and out.
The thing is I think Cain and Stipe can mix it up with boxing / kick boxing and wrestling and they will find great success in that.. I've seen some highlights from an older fight of Francis and I did see some holes maybe he improved them quite a bit or his working on improving them with every camp but for a good grappler, high level ones that can mix it up like Cain and Stipe I they they will prove to be to much for him.
Reem is also tricky, don't be fooled Reem is by fast the best kick boxer in the division if not the UFC and knows what to look for and how to time you, set traps etc high level stuff that he got a shell shocked JDS but still he out classed him in that outing.. I feel the raw Francis won't have much standing in terms of overall skills for Reem then again if you pressure him and does some mistakes like how he was close in doing vs Mark turning away and doing his running man move while getting crowded who knows.. his chin is done at this point and if he lands it's all over but from a technical standpoint as we speak he has nothing for the Reem.
JDS has the better boxing and has plenty of power in his right hand to put Francis down.. if I would make a ranking of what fight it's easier for Francis it's like this:
1. Werdum (easiest fight for him from all the top guys.. he will try to goof around and get him down he will fail.. they will play the stand up game he will land more but that 1 hard shot from Francis will come and he will be out)
2. JDS (kinda gets hit a lot, me thinks he will get touched and will go down)
3. Reem (he will out smart him and out play him but if he get crowded 1 single time and Francis land it's all over)
4. Stipe (way better technical boxing.. miles better but has issue in defense especially against left hands.. then again he can mix it up with wrestling and win it like that to, hard ass fight for Francis)
5. Cain (big danger he will be chain wrestled down and abused via GnP he has some defensive issues standing that's Francis window that he can find success)