It is true that in most of MacFarlane's shows, the women are the running joke. In Family Guy, Lois takes Peter's abuse with a smile, and Meg is the goto scapegoat anytime they literally need someone to shit on. In American Dad, Francine is a complete imbecile who has no clue about anything around her. They don't really have any "strong" females, although there is the occasional episode where Meg stands up for herself, and Lois acts like she did in season 1 (a normal down to earth mom, rationalizing her husband's idiocy).
At least shows like Simpsons, South Park, etc. know how to use comedy while also not making every female a total moron. Randy's wife Sharon totally sees how crazy and unpredictable her husband is, and is really only sticking around for the kids. Wendy is arguably the smartest and most self aware character on South Park, she has been since the beginning in the late 90's. Marge and Lisa have half the episodes dedicated to their adventures.
But y'know, it's just bro humor. *shrug*