Question regarding The Anaerobic Glycolytic system?

Discussion in 'Strength & Conditioning Discussion' started by Nedrin, Mar 14, 2017.

  1. Nedrin Green Belt

    Nedrin
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    I've tried understanding it by reading all kinds of articles/MMA Conditioning, but I'm kind of at a loss.

    So blood sugar gets converted to Pyruvate which is then converted to lactate (which can be converted back to Pyruvate).

    This system kickstarts when the energy production of the Aerobic system no longer provides enough energy for the given exercise.

    What I don't really understand, is it the lactate that gets used as energy as in lactate gets converted to ATP?

    So am I correct in understanding that we fatigue when lactate gets accumulated in the working muscle and it can no longer be transported away to be used by the Aerobic energy system?

    I know this question is kind of all over the place but I find it hard to describe something that I don't understand. I hope the terms give some kind of indication of what I know which could be helpful in answering the question.

    Thanks!
     
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  2. MandirigmaFit Blue Belt

    MandirigmaFit
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    It is not the lactate itself, but the change in pH (becomes more acidic) when the work intensity becomes too high for oxygen to be used by the muscle cells. The causes are from a build-up of H+ which causes an inhibition of certain enzymes needed to re-phosphorylate ADP into ATP. ADP and AMP also inhibit PFK, which is needed to break glycogen and glucose into pyruvate or lactate.

    Temperature and pH also both change enzyme capabilities.

    Lactate can be shuttled into the liver to be converted into a different energy substrate. Look up the Lactate-shuttle.
     
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  3. LatFlare EADC

    LatFlare
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    re your sig, i would bite the balls or pussy in a triangle. check mate bish.
     
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  4. Noodles03 Orange Belt

    Noodles03
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    I have nothing to contribute except for the fact I just survive 2 months of Cross Fit with out getting any injuries.

    [​IMG]
     
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  5. Thunderhead Assman Extraordinaire

    Thunderhead
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    Your arm will be in the way.



    Try again.
     
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  6. LatFlare EADC

    LatFlare
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    Fight me irl
     
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  7. Thunderhead Assman Extraordinaire

    Thunderhead
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    You want to bite my balls?
     
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  8. LatFlare EADC

    LatFlare
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    yes
     
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  9. Midnighter Black Belt

    Midnighter
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    Lactate doesn't get converted into ATP. The conversion of Pyruvate into Lactate releases NAD+.

    Without NAD+ glycolysis would stop.

    Lactate isn't involved in Aerobic respiration.

    Low pH from lactic acid build up inhibits phosphofructokinase which stops glycolysis.

    PFK transfers a phosphate from F-6-P to make F-1,6-BP and ATP was used for this. F-1,6-BP to Phosphoenolpyruvate produces ATP, if that's what you meant.

    Low energy (ADP/AMP) stimulate PFK. High levels of ATP inhibit PFK so that glycolysis will be inhibited and gluconeogensis will occur.

    I think everything I've said is right...my biochem is a little rusty.

    [​IMG]
     
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  10. MandirigmaFit Blue Belt

    MandirigmaFit
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    @Midnighter

    Actually, I am almost sure that you are right and I have gotten that backwards, but fortunately for me, that gives me something to review. So a win for both of us.
     
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  11. Midnighter Black Belt

    Midnighter
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    I just had it last semester and I honestly forgot like 90% of what I learned, so yea lol.
     
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