Originally Posted by SAAMAG
Learn to make a proper fist (your thumb doesn't fall on the front of your fist). Then learn to punch properly after that. Then you wont feel the need to make a thread like this. It's been discussed ad-nausea that both sets of knuckles are used to punch with, really only depending on what style of fighting you learned to punch in.
It doesn't fall on the front of the fist. My thumb over covers my index finger and it doesn't go over my index and middle finger like most people.
I make my fist the same way as Muhammed Ali.
Notice how his thumb only goes over the first finger? That's the same as mine and If I strike with the top two knuckles, I hit the knuckle of the thumb.